U1 small nuclear ribonucleoprotein 70kD Ab [Presence] in Serum by Line blot 82450-8
LOINC Code
LOINC code
82450-8
name
U1 small nuclear ribonucleoprotein 70kD Ab [Presence] in Serum by Line blot
description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
status
ACTIVE
Fully-Specified Name
component
U1 small nuclear ribonucleoprotein 70kD Ab
property
PrThr = Present or threshold: The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold.
time
Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
Line blot = Line blot: A membrane strip pre-coated with a specific set of antigens in parallel lines that are incubated with antibodies in order to detect the targets of interest.
Additional Names
short name
U1 snRNP70 Ab Ser Ql Line blot
Basic Attributes
class
SERO
type
1 Laboratory
order vs. observation
Both
Associated Observations
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Related Names
ABS Aby Antby Anti Antibodies Antibody Autoantibodies Autoantibody Nuc Ordinal Point in time PR QL Qual Qualitative Random
Ribonuclear protein Ribonucleoprotein extractable nuclear 68/70kD Ab Ribonucleoprotein extractable nuclear 68kD Ab Ribonucleoprotein extractable nuclear 70kD Ab RNP Screen Serology Serum snRNP snRNP70 SR U1 RNP U1 snRNP U1 snRNP70 U1RNP
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