PD-L1 by clone 22C3 [Interpretation] in Tissue by Immune stain Narrative 83054-7
LOINC Code
| LOINC code | 83054-7 | ||
|---|---|---|---|
| name | PD-L1 by clone 22C3 [Interpretation] in Tissue by Immune stain Narrative | ||
| description | This term should be used to report the narrative impression of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 22C3. Patients with certain cancers, such as non-small cell lung cancer (NSCLC), whose tumors are positive for PD-L1 by 22C3 may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC:83053-9], and the ordinal result for PD-L1 expression using [LOINC: 83052-1]. This term was created for, but is not limited in use to, the Dako PD-L1 22C3 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with specific cancers are eligible for pembrolizumab therapy. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Programmed cell death ligand 1 by clone 22C3 | ||
| property | Imp = Impression/interpretation of study | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Tiss = Tissue, unspecified | ||
| scale | Nar = Narrative: Text narrative, such as the description of a microscopic part of a surgical papule test. | ||
| method | Immune stain | ||
Additional Names | |||
| short name | PD-L1 by 22C3 Tiss ImStn-Imp | ||
Basic Attributes | |||
| class | PATH | ||
| type | 1 Laboratory | ||
| order vs. observation | Observation | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| test rank | 19499 of 2000 most commonly performed tests by labs in USA | ||
| first released | |||
| last updated | 2.73 | ||
| last change type | MIN - change to field other than name | ||
Related Names | |||
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