PD-L1 by clone SP142 [Presence] in Tissue by Immune stain 83057-0
LOINC Code
| LOINC code | 83057-0 | ||
|---|---|---|---|
| name | PD-L1 by clone SP142 [Presence] in Tissue by Immune stain | ||
| description | This term should be used to report the degree of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone SP142. Patients with certain cancers, such as non small cell lung cancer (NSCLC) or urothelial carcinoma, whose tumors are positive for PD-L1 by SP142, may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC: 83053-9]. If at least 50% of tumor cells or at least 10% of inflammatory cells stain positive with SP142, the tumor is considered to have high PD-L1 expression, and if 1 to 50% of tumor cells and 1 to 10% of inflammatory cells stain positive, the tumor has low expression. If <1% of both tumor and inflammatory cells stain positive, the tumor is considered to have no PD-L1 expression. This term was created for, but is not limited in use to, the Ventana PD-L1 (SP142) assay, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for atezolizumab therapy. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Programmed cell death ligand 1 by clone SP142 | ||
| property | PrThr = Present or threshold: The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold. | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Tiss = Tissue, unspecified | ||
| scale | Ord = Ordinal: Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive. | ||
| method | Immune stain | ||
Additional Names | |||
| short name | PD-L1 by SP142 Tiss Ql ImStn | ||
Basic Attributes | |||
| class | PATH | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| test rank | 17666 of 2000 most commonly performed tests by labs in USA | ||
| first released | |||
| last updated | 2.73 | ||
| last change type | MIN - change to field other than name | ||
Related Names | |||
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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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