Mutations/Megabase [# Ratio] in Tumor   94076-7

LOINC Code


LOINC code94076-7
nameMutations/Megabase [# Ratio] in Tumor
descriptionTumor mutation/mutational burden (TMB), also known as mutation load, is a biomarker for various cancer types to identify patients who will benefit from immunotherapy, such as immune checkpoint blockade (ICB) therapy.[PMID: 30395155] Various quantitative and ordinal results may be reported, so it is important to distinguish the type of results when mapping to LOINC. Quantitative results typically include the number of mutations detected per megabase (mut/Mb), often by NGS, in a tumor specimen (this term). The mutations targeted may include non-synonymous or both synonymous and non-synonymous mutations. An ordinal TMB result [LOINC: 94077-5] of high, low, etc., may also be reported to provide an overall interpretation for the quantitative value (muts/Mb). We encourage labs to report how results are determined or calculated in either the structured message format or using another LOINC.
statusACTIVE

Fully-Specified Name

componentMutations/Megabase
propertyNRto  =  Number Ratio
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemTumor
scaleQn  =  Quantitative:  The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256
method

Additional Names

short nameMuts/Mb Tumor

Basic Attributes

classMOLPATH.MUT
type1  Laboratory
order vs. observationObservation
example UCUM units{muts}/{Mb}
The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org)
example unitmuts/Mb

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

first released
last updated2.67
last change typeADD  - added

Related Names

Cancer
Mb
Molecular pathology
MOLPATH
MOLPATH.MUTATIONS
Mut
Mutation
Muts
Muts/Mb
Number ratio
Point in time
QNT
Quan
Quant
Quantitative
Random
TMB
Tumor mutation burden
Tumor mutational load
tumors
tumour
tumours

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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