UGT1A1 gene TA repeats [Genotype] in Blood or Tissue by Molecular genetics method Nominal 95143-4
LOINC Code
| LOINC code | 95143-4 | ||
|---|---|---|---|
| name | UGT1A1 gene TA repeats [Genotype] in Blood or Tissue by Molecular genetics method Nominal | ||
| description | The patient's genotype (e.g. TA5/TA7) for the TA repeat variant within the UGT1A1 gene. Variants include TA5 or *36: c.−41_-40delTA (g.234668893_234668894), TA7 or *28: c.−41_-40dupTA (g.234668893_234668894), and TA8 or *37: c.−43_-40dupTATA (g. 234668891_234668894). Testing is performed to screen for variants associated with increased risk of adverse drug reactions when taking UGT1A1-metabolized drugs, including pazopanib, nilotinib, atazanavir, and belinostat. Patient's homozygosity for the TA7 promoter variant (*28) have reduced UGT1A1 activity (about 30% to 50%) compared to normal.[PMID: 7565971] | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | UGT1A1 gene.TA repeats | ||
| property | Geno = Genotype | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Bld/Tiss Bld = Whole blood Tiss = Tissue, unspecified | ||
| scale | Nom = Nominal: Nominal or categorical responses that do not have a natural ordering. (e.g., names of bacteria, reported as answers, categories of appearance that do not have a natural ordering, such as, yellow, clear, bloody. | ||
| method | Molgen = Molecular Genetics: General class of methods used to detect genetic attributes on a molecular basis including RFL, PCR and other methods. | ||
Additional Names | |||
| short name | UGT1A1 TA Geno Bld/T | ||
Basic Attributes | |||
| class | MOLPATH.PHARMG | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.68 | ||
| last change type | ADD - added | ||
Related Names | |||
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