ABL1 gene c.944C>T [Presence] in Blood or Marrow by Molecular genetics method   95550-0

LOINC Code


LOINC code95550-0
nameABL1 gene c.944C>T [Presence] in Blood or Marrow by Molecular genetics method
descriptionDetection of the single-point mutation, T315I, in the ABL1 gene within the BCR-ABL1 fusion transcript. Early detection of T315I mutation in patient's with chronic myeloid leukemia (CML) could inform alternative treatment before resistance is detected cytogenetically or before disease progression become evident. Mutations in the kinase domain of the BCR-ABL1 fusion are the leading cause of acquired imatinib resistance. Although mutations have been identified in more than 30 different amino acids, the highest degree of resistance is found to be associated with the T315I mutation.
statusACTIVE

Fully-Specified Name

componentABL1 gene.c.944C>T
propertyPrThr  =  Present or threshold:  The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold.
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemBld/Bone mar
    Bone mar  =  Marrow (bone)
    Bld  =  Whole blood
scaleOrd  =  Ordinal:  Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive.
methodMolgen  =  Molecular Genetics:  General class of methods used to detect genetic attributes on a molecular basis including RFL, PCR and other methods.

Additional Names

short nameABL1 c.944C>T Bld/Mar Ql

Basic Attributes

classMOLPATH.MUT
type1  Laboratory
order vs. observationBoth

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

first released
last updated2.69
last change typeADD  - added

Related Names

ABL
ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL1 c.944C>
T
bcr/abl
Bld/Mar
Blood
BM
BON
Bone marrow
c-ABL
c-ABL1
CHDSKM
Chronic myeloid leukemia
Genetics
Heredity
Heritable
Inherited
JTK7
MAR
Marrow (bone)
minimal angle of resolution
Minimum angle of resolution
Molecular genetics
Molecular pathology
MOLPATH
MOLPATH.MUTATIONS
NM_005157.6(ABL1):c.944C>
T (p.Thr315Ile)
Ordinal
p150
PCR
Point in time
PR
QL
Qual
Qualitative
Random
Screen
T prime
T315I
v-abl
v-abl Abelson murine leukemia viral oncogene homolog 1
WB
Whole blood
Whole blood or Bone marrow

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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