CPT Knowledgebase - Feb 14, 2019

What is the appropriate CPT code to report promoter methylation analysis of BRCA1 and RAD51C performed via pyrosequencing using DNA isolated from formalin-fixed paraffin-embedded (FFPE) tumor tissue? Code 81287, MGMT (O-6-methylguanine-DNA methyltransferase) (eg, glioblastoma multiforme), methylation analysis, seems to be the closest description because it indicates methylation in the descriptor language; however, it specifically states MGMT.

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