Lupus anticoagulant aPTT and dRVVT screening panel W Reflex   75515-7

LOINC Code


LOINC code75515-7
nameLupus anticoagulant aPTT and dRVVT screening panel W Reflex
descriptionThe development of this panel for detecting Lupus Anticoagulant (LA) was shaped by the 2009 International Society of Thrombosis and Haemostasis (ISTH) and 2014 Clinical and Laboratory Standards Institute (CLSI) guidelines for lupus anticoagulant testing. They both recommend using two separate coagulation tests and identify dRVVT and aPPT as the two best choices. This aPPT & dRVVT panel is most closely aligned with the ISTH guidelines. The testing cascade starts with the use of the two above-named tests to screen for or verify a clotting abnormality, and if either is abnormal, reflexing to the same test with 1:1 pooled plasma (to exclude clotting factor deficiencies) and again with excess phospholipid (PL). Correction of the coagulopathy with excess phospholipid confirms the likelihood of LA. Neither published guidance nor laboratories agree on the order in which the two kinds of reflex tests should be done, and this panel does not take a position on that subject. Some laboratories report the absolute values of the test and some the normalized ratios. So LOINC includes both as alternatives. Only one or the other of the alternatives must be included in the panel report. A summary interpretation is required by both guidelines.
statusACTIVE

Fully-Specified Name

componentLupus anticoagulant two screening tests W Reflex panel
property-
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemPPP  =  Platelet poor plasma
scale-
methodCoag  =  Coagulation Assay:  To distinguish coagulation assays based on clotting methods that test function/activity from Immune methods that detect the presence of clotting factors and may or may not be functional assays.

Additional Names

short nameLA aPTT+dRVVT screen W reflex panel

Basic Attributes

classPANEL.COAG
type1  Laboratory
order vs. observationOrder

Panel Components

6303-2dRVVT (LA screen)
15359-3dRVVT actual/normal (normalized LA screen)
93234-3dRVVT in Platelet poor plasma by Coagulation assay --post heparin neutralization
75513-2dRVVT with 1:1 PNP (LA mix)
75512-4dRVVT with 1:1 PNP actual/normal (normalized LA mix)
93240-0dRVVT factor substitution in Platelet poor plasma by Coagulation assay --immediately after 1:1 addition of normal plasma and heparin neutralization
57838-5dRVVT W excess phospholipid (LA confirm)
68916-6dRVVT W excess phospholipid actual/normal (normalized LA confirm)
93238-4dRVVT excess phospholipid in Platelet poor plasma by Coagulation assay --post heparin neutralization
93239-2dRVVT excess phospholipid actual/normal in Platelet poor plasma by Coagulation assay --post heparin neutralization
50410-0dRVVT/dRVVT W excess phospholipid (screen to confirm ratio)
75511-6dRVVT W excess phospholipid percent correction
34571-0aPTT.lupus sensitive (LA screen)
48022-8aPTT.lupus sensitive actual/normal (normalized LA screen)
93235-0aPTT.lupus sensitive in Platelet poor plasma by Coagulation assay --post heparin neutralization
75510-8aPTT.lupus sensitive with 1:1 PNP (LA mix)
75509-0aPTT.lupus sensitive with 1:1 PNP actual/Normal (normalized LA mix)
75506-6aPTT.lupus sensitive W excess phospholipid (LA confirm)
75508-2aPTT.lupus sensitive W excess phospholipid actual/Normal (normalized LA confirm)
93236-8aPTT.lupus sensitive.excess phospholipid in Platelet poor plasma by Coagulation assay --post heparin neutralization
93237-6aPTT.lupus sensitive.excess phospholipid actual/normal in Platelet poor plasma by Coagulation assay --post heparin neutralization
75884-7aPTT.lupus sensitive/aPTT.lupus sensitive W excess phospholipid (screen to confirm ratio)
75507-4aPTT.lupus sensitive W excess phospholipid percent correction
75514-0Lupus anticoagulant two screening tests W Reflex [interpretation]

Associated Observations

LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations.

History/Usage

first released
last updated2.67
last change typePANEL  - addition or removal of child elements or change in the conditionality of child elements in the panel or in sub-panels contained by the panel.

Related Names

2
Anticoag
Anti-phospholipid antibody
aPTT-LA
Asympt
Asymptomatic
Clot
Clottable
COAGULATION
Coagulation assay
Coagulation inhibiting antibody
Dil Russell Vip Ven
dRVVT
LA
LA 2 screen W Reflex
LA 2 screen W Reflex pnl
LAC
Lupus inhibitor
Pan
PANEL.COAGULATION
Panl
Plas
Platelet poor plasma
Pnl
Point in time
Random
Scn
Tilt tube

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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