Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex 75881-3
LOINC Code
| LOINC code | 75881-3 | ||
|---|---|---|---|
| name | Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex | ||
| description | The lupus anticoagulant three screen panel is based primarily on the 2009 International Society of Thrombosis and Haemostasis (ISTH) and 2014 Clinical and Laboratory Standards Institute (CLSI) guidelines for detecting the presence of lupus anticoagulants (LA), with some modifications based on information from major laboratories that use three screening tests (PT, aPTT and dRVVT) as the first step in LA testing. The ISTH guidelines recommend using dRVVT as the first screening test and aPTT-LA as the second screening test, followed by reflex to mixing studies with 1:1 Pooled Normal Plasma and confirmatory testing with excess phospholipid (PL) if either of the screening tests are positive. The CLSI guidelines permit use of other screening tests in addition to aPTT and dRVVT, and also recommend changing the order of the tests to screening following by confirmatory and then mixing. Some major laboratories reflex to thrombin time (TT) and reptilase assays if any of the three screening tests have an abnormal result, so both of those tests are included in the panel. Both ISTH and CLSI recommend reporting quantitative results as the ratio of the patient result to the control result for each of the screening, mixing and confirmatory tests that are performed. However, they use different parameters for the control: ISTH recommends calculating the control based on pooled normal plasma (PNP), while CLSI recommends using the mean of the reference interval provided by the assay manufacturer. Many labs report either the actual patient result or the actual patient result and the actual/normal ratio, so we have included both options in the panel. In addition to the quantitative results, both guidelines recommend reporting a qualitative interpretation. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Lupus anticoagulant three screening tests W Reflex panel | ||
| property | - | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | PPP = Platelet poor plasma | ||
| scale | - | ||
| method | Coag = Coagulation Assay: To distinguish coagulation assays based on clotting methods that test function/activity from Immune methods that detect the presence of clotting factors and may or may not be functional assays. | ||
Additional Names | |||
| short name | LA aPTT+dRVVT+PT W Reflex PPP | ||
Basic Attributes | |||
| class | PANEL.COAG | ||
| type | 1 Laboratory | ||
| order vs. observation | Order | ||
Panel Components | |||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.67 | ||
| last change type | PANEL - addition or removal of child elements or change in the conditionality of child elements in the panel or in sub-panels contained by the panel. | ||
Related Names | |||
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